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FLASH GENE
Symbol FUT4 contributors: mct - updated : 29-06-2020
HGNC name fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
HGNC id 4015
Location 11q21      Physical location : 94.277.016 - 94.283.062
Synonym name
  • ELAM ligand fucosyltransferase
  • FIM-1 lignad fucosyltransferase
  • Synonym symbol(s) ELFT, FCT3A, CD15, FucT-IV, CD15, FUTIV, LeX, SSEA-1
    EC.number 2.4.1.152
    DNA
    TYPE functioning gene
    STRUCTURE 6.05 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - TYR - D19S388 - FUT4 - D19S919 - D19S35 - NCAM1 - qter
    Authors Reguigne (94)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 6063 46 530 - 2019 31104223
    FUT4L
    - splicing 2150 - 405 myeloid cell lines, colon adenocarcinoma cell lines 2019 31104223
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage myeloid cells lines
    cell lines colon adenocarnoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Fut4
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • important regulator of inflammatory events
  • may catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1
  • and VIM-2 antigens
  • is an essential enzyme that catalyzes the synthesis of fucosylated oligosaccharides by transferring GDP-fucose to the terminal N-acetylglucosamine with the alpha1,3-linkage
  • CLDN4 and FUT4 are representative genes that participate in modulating trophoblast mobility
  • is associated with the proliferation and metastasis of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FUT4 is a target gene for HSF1 and SP1 that is required for cell cycle progression in breast cancer epithelial cells
  • FUT4-, FUT6- or FUT8-mediated multidrug resistance (MDR) in hepatocellular carcinoma is associated with the activation of the PI3K/Akt pathway and the expression of ABCC1
  • SMYD2 affects cell proliferation, invasion, and apoptosis of colon cancer cells via the regulation of ERBB2/FUT4 signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon adenocarcinoma and myeloid cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • FUT4 can serve as novel biomarker in the diagnosis and prognosis of breast cancer
  • is a sensitive and specific marker for intraepithelial and invasive neoplasias of the bile duct
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers
    ANIMAL & CELL MODELS