basic FUNCTION
| involved in recombination or mismatch repair by interacting with MSH2 |
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playing a role in events at the replication sites as well as a functional role in the DNA mismatch repair and/or recombination processes |
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nuclease implicated in a multitude of eukaryotic DNA metabolic pathways that include DNA repair, recombination, replication, and telomere integrity |
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plays both structural and catalytic roles during DNA mismatch repair |
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playing a role with BLM in the initiation of recombinational DNA repair |
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has a role in the timely induction of apoptosis, is subsequently cleaved and degraded during apoptosis, potentially inhibiting DNA damage repair |
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new functions of RBBP8 and EXO1 in DNA end resection, preventing genomic instability |
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PIF1 and EXO1 resect telomeric DNA <5 kb from the chromosome end, stimulating weak checkpoint activation; resection is extended >5 kb by EXO1 and full checkpoint activation occurs |
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ERCC5 and EXO1 may have an analogous disorder-to-order transition promoted by ssDNA or a partner |
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FEN1, EXO1, ERCC5, and GEN1 are junction specific enzymes that require three separate binding sites for DNA and that incise one base pair into the duplex region of the substrate |
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involved in the cellular response to UV irradiation in human cells |
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key role in the UV-induced DNA damage response linking nucleotide excision repairto checkpoint activation in human cells |
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potential cross-talk between DNA2- and EXO1-dependent resection pathways |
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multifunctional exonuclease involved in DNA damage repair, replication, immunoglobulin diversity, meiosis, and telomere maintenance |
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encodes both structural and catalytic functions that play distinct roles in essential biological processes |
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catalytic function of EXO1 is required for its participation in mismatch repair |
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coupling of EXO1 activation with its eventual degradation is a timing mechanism that limits the extent of DNA end resection for accurate DNA repair |
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is an evolutionarily conserved eukaryotic nuclease that plays a multifaceted role in maintaining genome stability |
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plays a key role in the resolution of, and replication through, telomeric G-quadruplexes |
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ability to resect DNA in the 5'-3' direction shown to be implicated in several genomic DNA metabolic processes such as replication stress response, double strand break repair, mismatch repair, nucleotide excision repair and telomere maintenance |