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Symbol RPL41 contributors: SGE/npt - updated : 06-04-2010
HGNC name ribosomal protein L41
HGNC id 10354
Location 12q14      Physical location : 56.510.373 - 56.511.615
Synonym name
  • homologue of yeast ribosomal protein YL41
  • HG12 protein
  • 60S ribosomal protein L41
  • Synonym symbol(s) HG12
    DNA
    TYPE functioning gene
    STRUCTURE 1.24 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 478 - 25 - Klaudiny (1992)
    3 - 593 - 25 - Klaudiny (1992)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein L41e family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • 60S ribosomal protein L41
  • can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II alpha by CKII (Lee 1997)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly down-regulated in carcinoma cell lines (Sim 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS