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FLASH GENE
Symbol F2RL2 contributors: npt/mct - updated : 23/12/2008
HGNC name coagulation factor II (thrombin) receptor-like 2
HGNC id 3539
Location 5q13      Physical location : 75.911.307 - 75.919.240
Synonym name
  • protease-activated receptor 3
  • thrombin receptor-like 2
  • Synonym symbol(s) PAR3, PAR-3
    DNA
    TYPE like-sequence
    STRUCTURE 7.93 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3427 42 374 - Ostrowska (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmegakaryocyte
    Blood/Hematopoieticplatelet
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor including a sequence with F2RL3 in the extracellular domain
  • multiple PDZ domains (second PDZ domain binds to phosphatidylinositol (PI) lipid membranes with high affinity) (Wu 2007)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine F2rl2
    homolog to C.elegans T22D1.12
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins
  • member of the protease-activated receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cofactor for F2RL3 activation by thrombin
  • mediating thrombin-triggered phosphoinositide hydrolysis
  • thrombin receptor
  • able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses
  • involved in the invasive phase of placentation
  • required for polarity in diverse cell types (Wu 2007)
  • ideal scaffold protein for integrating PIP signaling events during cellular polarization (Wu 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text blood coagulation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with F2R (critical determinant of F2R function, targeting of F2RL2 may mitigate the effects of F2R in activating endothelial responses such as vascular inflammation)
  • interacting with F2RL3
  • cell & other
    REGULATION
    activated by proteases including thrombin, proteolytic cleavage of its extracellular N terminus, generating a new receptor N terminus which functions as a tethered ligand and activates the receptor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice deficient in Par3 (Kahn, 1998)