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FLASH GENE

Symbol

LRP3

contributors: npt - updated : 16-11-2006

HGNC name	low density lipoprotein receptor-related protein 3
HGNC id	6695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q12-q13.2      Physical location : 33.685.598 - 33.699.767

DNA

TYPE	functioning gene
STRUCTURE	13.05 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3698 82.9 770 - Ishii variant 2 - - 4400 - - - Ishii

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Endocrine pancreas         Nervous brain       highly Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	two isoleucine/leucine/value rich regions
	a RGD sequence
	two ligand-binding repeat regions TM segments
	a proline-rich cytoplasmic region

HOMOLOGY

interspecies

homolog to rattus lrp3

intraspecies

homolog to low density lipoprotein receptor 3 (LDLR)

Homologene

FAMILY

low density lipoprotein receptor (LDLR) family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane protein

basic FUNCTION	receptor mediated endocytosis
	having a role other than lipoprotein metabolism

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

endocytosis transport

text	receptor mediated endocytosis

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS