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FLASH GENE
Symbol SWAP70 contributors: npt/mct - updated : 14-03-2023
HGNC name switching B cell complex subunit SWAP70
HGNC id 17070
Location 11p15.4      Physical location : 9.685.627 - 9.774.505
Genatlas name SWAP-70 protein
Synonym name
  • cDNA sequence, expressed in brain, 66kDa, related to Drosophila myosin heavy chain
  • SWAP switching B-cell complex 70kDa subunit
  • SWAP complex protein 70kDa
  • switch-associated protein 70
  • Synonym symbol(s) KIAA0640, EVI83, HSPC321, FLJ39540, SWAP-70
    DNA
    TYPE functioning gene
    STRUCTURE 88.92 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4884 69 585 - 2020 31932501
    11 - 4710 - 527 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Respiratoryrespiratory tractlarynx  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three nuclear localization signals (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila myosin heavy chain
    Homologene
    FAMILY
  • pleckstrin-like family
  • SWEF family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • recruited to early phagosomes of macrophages and dendritic cells
  • basic FUNCTION
  • . acting as a link between the recognition of specific switch regions and causation of a DNA break
  • multiple functional signaling protein involved in formation of membrane ruffling induced by signal cascade of tyrosine kinase growth factor receptors
  • may be involved in regulating migration and invasion of trophoblast cells during the processes of embryonic implantation and placentation
  • regulates the actin cytoskeleton as an effector or adaptor protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion
  • F-actin-binding, Rho GTPase-interacting protein strongly expressed in activated B cells, that is necessary for normal B-cell migration
  • regulates integrin-mediated adhesion and cell attachment
  • as SWAP70 has been shown to be the last protein to receive signals from cytokines, it is likely that there is a putative feedback signaling pathway, and that disorder of this signaling pathway can transform cells
  • restricts spontaneous maturation of dendritic cells
  • SWAP70 and DEF6 regulate hematopoietic stem cells/progenitor homeostasis, self-renewal, lineage contributions and repopulation in a distinct and mostly antagonistic manner
  • key role for SWAP70 as a scaffold for tethering the peripheral actin cage to phagosomes
  • key role for SWAP70 as the tethering factor stabilizing F-actin filaments on the surface of phagosomes in human dendritic cells by interacting both with Rho-family GTPases and the lipid phosphatidylinositol (3,4)-bisphosphate
  • essential and specific role for SWAP70 in tethering and stabilizing F-actin to the phagosomal surface in a wide range of phagocytes
  • SWAP70 and DEF6-mediated restriction of dendritic cell (DC) differentiation converges mechanistically at the NFKB1 pathway
  • SWAP70 is a protective molecule that can suppress the progression of nonalcoholic fatty liver disease by inhibiting hepatic steatosis and inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of an enzyme complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to F-actin
  • cooperates with Rac
  • binding activity of SWAP70 to non-muscle F-actin is required for membrane ruffling
  • important target of SYK in migration and polarization of naive recirculating B cells
  • Rho GTPase-regulatory protein that control both cytoskeletal dynamics and the activity of the transcription factor IRF4 (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS