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FLASH GENE
Symbol TAF6 contributors: mct - updated : 02-06-2020
HGNC name TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
HGNC id 11540
Corresponding disease
ALYUS Alazami-Yuan syndrome
Location 7q22.1      Physical location : 99.704.693 - 99.717.481
Synonym name
  • transcription initiation factor TFIID 70 kD subunit
  • transcription initiation factor TFIID subunit 6
  • RNA polymerase II TBP-associated factor subunit E
  • Synonym symbol(s) TAFII70, TAFII80, TAFII85, TAF2E, MGC:8964, DKFZp781E21155, ALYUS, TAF(II)70, TAF(II)80, TAFII-70, TAFII-80,
    DNA
    TYPE functioning gene
    STRUCTURE 20.14 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 splicing 2748 72.7 677 - 2014 25025302
    - splicing 2380 - 667 - 2014 25025302
    15 splicing 2707 - 667 - 2014 25025302
    15 splicing 2424 72.7 677 - 2014 25025302
    15 - 2433 - 714 - 2014 25025302
    16 - 2880 - 677 - 2014 25025302
    15 - 2718 - 667 - 2014 25025302
    TAF6delta
    16 - 2678 - 723 - 2014 25025302
    16 - 2526 - 667 - 2014 25025302
    TAF6delta
    17 - 2526 - 677 - 2014 25025302
    14 - 2394 - 667 - 2014 25025302
    TAF6 delta
    15 - 2269 - 667 - 2014 25025302
    TAF6delta
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouth   highly
     salivary gland   highly
    Endocrinethyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a small middle domain (TAF6M)
  • a large C-terminal domain (TAF6C)
  • HOMOLOGY
    Homologene
    FAMILY
  • TAF6 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • TAF6delta is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor, TAF6, that can dictate life vs. death decisions i cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • BCL2L11 and PMAIP1 are mitochondrial effectors of TAF6delta-driven apoptosis
  • key checkpoint function for the chaperonin TCP1, which specifically associates with nascent TAF5 for subsequent handover to TAF6-TAF9 and ultimate holo-TBP formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALYUS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS