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FLASH GENE
Symbol ATP6V0B contributors: mct - updated : 05-11-2010
HGNC name ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
HGNC id 861
Location 1p34.1      Physical location : 44.440.601 - 44.443.971
Synonym name
  • ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''. V-ATPase 21 kDa proteolipid subunit
  • V-ATPase subunit c''
  • H(+)-transporting two-sector ATPase, subunit
  • V-type proton ATPase 21 kDa proteolipid subunit
  • vacuolar ATP synthase 21 kDa proteolipid subunit; vacuolar proton pump 21 kDa proteolipid subunit; vacuolar proton pump, 21 kDa subunit
    • Synonym symbol(s) ATP6F, MATPL, VMA16, HATPL
    EC.number 3.6.3.34
    DNA
    TYPE functioning gene
    STRUCTURE 3.90 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • both GC-boxes and E-boxes
  • basal promoter to be highly complex, with cooperative binding of several transcription factors, including Sp family members.
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 979 - 158 - 2003 128905
    8 - 1028 - 205 - 2003 12890556
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     stomach   highly
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate  highly
    Respiratorylung    
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • five putative transmembrane segments (5TM)
  • a conserved glutamic and residue, essential for H+ transporting
    • HOMOLOGY
    interspecies homolog to yeast VMA16
    Homologene
    FAMILY
  • V-ATPase proteolipid subunit family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, vacuolar proton pump, microvesicles and other acidic organelles (lysosomes)
  • proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase
  • coupling ATP hydrolysis to proton pumping across membranes
  • conserved proton pumps that couple hydrolysis of cytosolic ATP to proton transport out of the cytosol
  • important role for physical association between aldolase and V-ATPase in the regulation of the proton pump
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS