basic FUNCTION
| playing an important roles in transcription, transcription-coupled nucleotide excision repair and base excision DNA repair |
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Swi/Snf-like RNA/DNA helicase homolog without active helicase activity |
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involved in transcription-coupled and global genome-DNA repair, as well as in general transcription |
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contributing to base excision repair (BER) of 8-hydroxyguanine (OGG1) through motifs V and VI of the putative helicase domains |
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playing a role in the transcriptionnal bypass of some oxidative DNA damage, and implicated in transcription-coupled repair, transcriptional elongation, and restoration of RNA synthesis after DNA damage |
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stimulates elongation of RNA Pol I in an ATP-independent manner |
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recruits nucleotide excision repair factors to the DNA damage site and plays an important role in the repair process |
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playing a general role in maintenance and remodeling of chromatin structure |
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positively cooperates in ATP hydrolysis as a function of protein concentration |
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playing a role in the repair of base excision repair substrates/intermediates, and a specific functional interaction with the predominant AP site repair enzyme, APEX1 |
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playing a role in the processing of base excision repair specific DNA substrates, potentially in regions of the genome that take on complex structures |
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has novel strand annealing and exchange activities |
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having a possible role as a signaling molecule in response to oxidative damage (tyrosine-phosphorylated ERCC6 may serve as a signal for repair proteins to localize to DNA damage and may help maintain active transcription in the nucleolus) |
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fulfills a key role as a coupling factor to attract histone acetyltransferase p300, nucleotide excision repair (NER) proteins |
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plays a role in repair of formamidopyrimidines, possibly by interacting with and stimulating NEIL1, and accumulation of such modifications may have a causal role in the pathogenesis of CS |
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ERCC6, ERCC8 are the key elements of a regulatory mechanism that equilibrate beneficial and detrimental effects of TP53 activity upon cellular stress |
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is a multifunctional protein regulating both repair and the transcriptional response to reactive oxygen through its interaction with EP300 and the HIF1 pathway |
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likely modulates cell viability in pluripotent stem cells, regulating the expression of TP53 and TXNIP and ROS production |
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function for ERCC6 in neural precursors |
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role of ERCC6 and ERCC8 protein in the oxidative stress response |
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ERCC6, ERCC8, in addition to their established role in transcription-coupled nucleotide excision repair, can modulate the base excision repair (BER) of oxidized DNA bases both directly (by interaction with BER proteins) and indirectly (by modulating the expression of the DNA repair genes) |
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biological role for ERCC6 and NEIL2 in transcription associated base excision repair |
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has a crucial role in coordinated regulation of transcription and chromatin remodeling activities that are required during neurogenesis |
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appears to behave as an electron scavenger in the mitochondria whose absence leads to increased oxidative stress |
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plays crucial roles in gene expression and the maintenance of genome integrity |
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ERCC6-PGBD3 fusion protein, like many other proteins that can cause POF, modulates or participates in DNA repair |
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critical for transcription-coupled-Nucleotide excision repair |