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FLASH GENE
Symbol NR6A1 contributors: mct - updated : 18-03-2008
HGNC name nuclear receptor subfamily 6, group A, member 1
HGNC id 7985
Location 9q33-q34.1      Physical location : 127.284.702 - 127.533.576
Synonym name
  • retinoic acid receptor-related testis-associated receptor
  • germ cell nuclear factor
  • Synonym symbol(s) RTR, GCNF, NR61, GCNF1
    DNA
    TYPE functioning gene
    STRUCTURE 248.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1918 54 480 - Susens, Rajkovic (2004)
    10 - 1903 - 476 - Susens, Rajkovic (2004)
    - - 4129 - 454 - Susens
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemplacenta  highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain
  • a central bipartite zinc finger
  • a DNA binding domain
  • a C terminal ligand domain
  • HOMOLOGY
    Homologene
    FAMILY
  • nuclear receptor subfamily 6, group A
  • steroid/thyroid receptor superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • germ cell nuclear receptor, potentially involved in spermatogenic maturation
  • required for establishment of the isthmic organizer, thereby regulating the midbrain development
  • playing a central role during differentiation of stem cells by repression of stem cell-specific genes
  • works as a regulator for hypocretin transcription
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with UIMC1
    cell & other
    REGULATION
    Other regulated by UIMC1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS