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FLASH GENE
Symbol PIK3C2B contributors: mct - updated : 03-09-2015
HGNC name phosphoinositide-3-kinase, class 2, beta polypeptide
HGNC id 8972
Location 1q32.1      Physical location : 204.391.758 - 204.459.474
Synonym name
  • PI3K-C2beta
  • PTDINS-3-kinase C2
  • Synonym symbol(s) C2-PI3K
    EC.number 2.7.1.137/ 2.7.1.154
    DNA
    TYPE functioning gene
    STRUCTURE 67.00 kb     34 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a universal Ca2+ binding domain (C2)
  • proline-rich motifs within the N terminus mediating the association with activated EGF receptor involving the GRB2 adaptor
  • HOMOLOGY
    Homologene
    FAMILY PI3/PI4-kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • may be involved in EGF and PDGF signaling cascades
  • plays a critical role in T-cell activation
  • both PI3KC2B and TRIM27 play critical but opposite roles in FCER1A-stimulated activation of KCNN4, Ca2+ influx, degranulation, and cytokine production in bone marrow mast cells
  • PI3KC2B and PIK3CG control distinct steps involved in cell migration supporting the hypothesis that different PI3Ks regulate distinct cellular processes
  • novel role for PI3KC2B in human neuroblastoma tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    calcium, magnesium, or manganese
    protein
  • associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transport
  • ITSN associated with PI3KC2B on a subset of endomembrane vesicles and enhanced both basal and growth factor-stimulated PI3KC2B activity, resulting in AKT activation
  • associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transportis activated by the T-cell receptor (TCR) and is critical for KCNN4 channel activation
  • TRIM27 functions as an E3 ligase and mediates lysine 48 polyubiquitination of PI3KC2B, leading to a decrease in PI3K enzyme activity
  • TRIM27 functions as an E3 ligase to ubiquitinate and inhibit PI3KC2B kinase activity
  • is also essential for FCER1A activation of KCNN4 and Ca2+ influx in mast cells and TRIM27 plays a similar role to negatively regulate KCNN4 channel activity and FCER1A activation of mast cells
  • cell & other
    REGULATION
    activated by GRB2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a potential new pharmacologic target to treat IgE-mediated disease
  • Marker
    Therapy target
    ANIMAL & CELL MODELS