basic FUNCTION
| polyspecific transporter for organic cations, sodium independent |
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non-neuronal monoamine transportersthat play a key role in the clearance of monoamines from extracellular compartments (Bottalico 2007) |
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involved in the hepatic uptake of organic cations (Umehara 2007) |
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transcription factor implicated in stress responses, metabolic control, and poised transcription states, regulates normal and pathologic stem cell function |
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regulates normal and cancer stem cell function |
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play a pivotal role in absorption, excretion, and tissue distribution of drugs and endogenous compounds, including neurotransmitters |
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membrane transporter that is important for therapeutic effect of the antidiabetic drug metformin |
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polyspecific transporter involved in the uptake of positively charged and neutral small molecules in the liver |
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plays a significant role in hepatic elimination of serotonin and xenobiotics may alter the elimination of endogenous compounds as a result of interactions at the transporter level |
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mediate the transport of organic cations including inhaled drugs across the cell membrane, in lung epithelium |
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is the dominant carrier of organic cationic drugs and some positively charged endogenous compounds into hepatocytes |
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role of SLC22A1 in the efflux of acylcarnitines from the liver to the circulation |
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is a cellular exporter of acylcarnitines in hepatocytes |
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SLC22A1 mediates transport between liver and blood and not between liver and bile |