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FLASH GENE
Symbol ANXA13 contributors: - updated : 27-04-2007
HGNC name annexin A13
HGNC id 536
Location 8q24.13-q24.2      Physical location : 124.693.034 - 124.749.647
Synonym name
  • annexin, intestine-specific
  • annexin XIII
  • Synonym symbol(s) ANX13, ISA
    DNA
    TYPE functioning gene
    STRUCTURE 56.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map see HAS2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1480 355 315 - Wice, Anderson
    - splicing 1590 - 357 - Iglesias, Anderson, Turnay
  • N-terminus destabilizes the conserved protein core, as deduced from the low melting temperature in the absence (44 degrees C) or presence of calcium (55 degrees C), and impairs calcium-dependent binding to acidic phospholipids
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon highly
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    Urinaryepithelial cell
    cell lineage undifferentiated, proliferating endothelial cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
  • conjugated Other
    HOMOLOGY
    interspecies homolog to C.elegans Sc155.1
    Homologene
    FAMILY annexin family
    CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text differentiated villus
    basic FUNCTION
  • playing a potential role in the balance between proliferation and differentiation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS