basic FUNCTION
| involved in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds |
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catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones |
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UGT2B15 and B17 are primary androgen-regulated genes and AR is required for both their basal expression and their androgen-regulated expression |
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may play a role in the metabolism of androgens in prostate tissue |
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sex difference in UGT2B17 gene expression and corresponding protein activity could potentially result in different levels of carcinogen detoxification or drug elimination in men versus women |
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play important roles in the glucuronidation of nicotine, cotinine, and trans-3'-hydroxycotinine (3HC) |