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FLASH GENE
Symbol B4GALT2 contributors: mct/npt - updated : 01-12-2015
HGNC name UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
HGNC id 925
Location 1p34-p33      Physical location : 44.444.865 - 44.456.839
Synonym name
  • UDP galactose:beta-N-acetylglucosamine beta 1,4,galactosyltransferase 2
  • lactose synthase A protein
  • N-acetyllactosamine synthase
  • Synonym symbol(s) B4GT2, beta4Gal-T2
    EC.number 2.4.1.38, 2.4.1.22, 2.4.1.90
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1950 - 136 - Almeida, Gregory (2006)
    non functional
    - - 1890 41 372 - Almeida, Gregory (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Reproductivefemale systemuteruscervix highly
     female systemovary   
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal hydrophobic signal sequence
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • beta-4- galactosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • trans Golgi
  • type II transmembrane glycoprotein
  • basic FUNCTION
  • synthesis of N acetylactosamine in glycolipids and glycoproteins
  • one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans and its expression is significantly altered during oncogenesis
  • play important roles in the extension of N- and O-linked glycans involved in several biological events
  • major regulator of the synthesis of glycans involved in neuronal development
  • specific enzyme complex of B4GALT2 with B3GAT1 plays an important role in the biosynthesis of B3GAT1 carbohydrate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha lactalbumin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS