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FLASH GENE
Symbol CTSE contributors: mct - updated : 01-06-2007
HGNC name cathepsin E
HGNC id 2530
Location 1q32.1      Physical location : 206.317.458 - 206.332.103
Synonym name
  • erythrocyte membrane aspartic proteinase
  • slow-moving proteinase
  • Synonym symbol(s) CATE
    EC.number 3.4.23.34
    DNA
    TYPE functioning gene
    STRUCTURE 14.65 kb     9 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure GATA1, PU1 and YY1 binding sites
    MAPPING cloned Y linked Y status confirmed
    Map cen - REN - CTSE - qter
    RNA
    TRANSCRIPTS type messenger
    text multiple transcripts from alternative polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2228 42.8 396 - Azuma (1992)
    8 splicing 2086 39 363 - Azuma (1992)
    different C terminals
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Lymphoid/Immunespleen    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunemacrophage
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text hepatocytes
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    intraspecies paralog to cathepsins
    homolog to highly homologous to the lysosomal aspartic protease cathepsin D
    Homologene
    FAMILY
  • eukaryotic aspartyl protease family
  • pepsin superfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • endolysosomal aspartic proteinase predominantly expressed in cells of the immune system, having an important role in immune responses
  • major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway
  • may play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain
  • playing an important role for preventing the accumulation of the lysosomal membrane sialoglycoproteins
  • playing an important role for exogenous antigen processing via the major histocompatibility complex class II presenting system
  • specifically induces tumor growth arrest and apoptosis in prostate carcinoma cell lines without affecting normal cells (Zaidi 2008)
  • important in the processing of tetanus toxin C-fragment in primary B cells
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer, disulfide-linked
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cell-specific transcription factors GATA1 and PU1
    inhibited by YY1 factor
    Other catalytic activity, propeptides, and N-glycosylation of this protein are all essential for its processing, maturation, and trafficking
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inducing a lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins (LAMP1, LAMP2, SCARB2) and the elevation of lysosomal pH in macrophages
    tumoral     --over  
    in gastric and cervical adenocarcinomas, in lung adenocarcinomas and squamous cell carcinomas, and in pancreatic ductal adenocarcinomas (Zaidi 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential marker for the inception and progression of intestinal cancers
  • Marker
    Therapy target
    ANIMAL & CELL MODELS