basic FUNCTION
| adapter protein involved in tyrosine phosphorylation of APP (Malinin 2005) |
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required for podosome formation, for degradation of the extracellular matrix, and for invasion of some cancer cells (Seals 2005) |
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scaffold protein that may serve as a specific recruiting adapter for various components during podosome formation (Crimaldi 2009) |
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plays a central role in the recruitment of AFAP1, GRLF1, and cortactin to drive podosome formation (Crimaldi 2009) |
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co-localizes to podosomes/invadopodia in different cancer cells and contribute to tumor progression (role of podosomes as mediators of tumor angiogenesis)(Blouw 2008) |
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important and novel role for the SRC-SH3PXD2A pathway in neural crest cell migration during embryonic development |
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SH3PXD2B, and SH3PXD2A are also required for proper embryonic development, probably because of their roles in cell migration |
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is crucial for osteoclast fusion downstream of phosphoinositide 3-kinase and SRC |
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may take part in the pathogenesis of pre-eclampsia (PE) through its role in the regulation of trophoblast cell invasion in the period of placenta formation |
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adaptor protein that is a major actor of the invadosome degradation function |
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is a scaffold protein and SRC substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function |
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is important for the integrity and permeability of the tumor vasculature |
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similar to AFAP1L2, plays a role in cell proliferation and cell survival and the interaction between AFAP1L2 and SH3PXD2A appears to be critical for regulation of SRC-mediated cellular homeostasis |
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importance of adaptor proteins SH3PXD2B, and SH3PXD2A in melanoma growth and metastasis, likely via functional invadopodia formation |