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FLASH GENE
Symbol RRP8 contributors: mct/npt - updated : 05-10-2016
HGNC name ribosomal RNA processing 8, methyltransferase, homolog (yeast)
HGNC id 29030
Location 11p15.4      Physical location : 6.621.153 - 6.624.811
Synonym name
  • KIAA0409
  • ribosomal RNA-processing protein 8
  • related to Saccharomyces pombe C56F8-09 protein,57kDa
  • RRP8 methyltransferase homolog (S. cerevisiae)
  • cerebral protein 1
  • nucleomethylin
  • Synonym symbol(s) KIAA0409, NML
    DNA
    TYPE functioning gene
    STRUCTURE 88.85 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1699 - 456 - 2000 10864042
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • motifs found in methyltransferases (Bousquet-Antonelli 2000)
  • HOMOLOGY
    interspecies homolog to yeast S.pombe C56F8-09 protein
    homolog to Drosophila CG7137
    homolog to C.elegans T07A9.8
    Homologene
    FAMILY
  • methyltransferase superfamily
  • RRP8 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text localizes to the nucleolus (Bousquet-Antonelli 2000)
    basic FUNCTION
  • methyltransferase activity
  • nucleolar protein functionally linked to GAR1 and involved in pre-rRNA cleavage at site A2 (Bousquet-Antonelli 2000)
  • nucleolar protein, important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which also contains SIRT1 and SUV39H1
  • RRP8 complex promotes rDNA heterochromatin formation and represses rRNA transcription
  • is required for the N(1)-methyladenosine (m(1)A) modification in 28S rRNAs of human cells
  • also contributes to 60S ribosomal subunit formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NMNAT1 interacts with the nucleolar repressor protein RRP8 and is involved in regulating rRNA transcription
  • RRP8-SIRT1 interaction was competitively inhibited by rRNA
  • RRP8-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a TP53-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS