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FLASH GENE
Symbol ABLIM1 contributors: - updated : 26-09-2006
HGNC name actin binding LIM protein 1
HGNC id 78
Location 10q25      Physical location : 116.190.869 - 116.444.414
Synonym name limatin
Synonym symbol(s) LIMAB1, KIAA0059, ABLIM, LIMATIN, MGC1224, DKFZp781D1048
DNA
TYPE functioning gene
STRUCTURE 227.00 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure high density of brain and CNS specific transcription factor' binding sites in the promoter region
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 7597 87 778 - -
- - 7704 - 746 - -
- splicing 7620 - 718 - -
differs from variant 1 in the 5'UTRand in the coding region
- - 6850 - 455 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal cysteine-rich LIM/double zinc finger motifs
  • a C terminal end homolog to actin-bundling domain of erythrocyte cytoskeleton (dematine like/villin headpiece domain (VHP))domain)
  • HOMOLOGY
    interspecies homolog to murine Ablim1
    intraspecies homolog to DEMATIN
    homolog to dematin
    Homologene
    FAMILY LIM protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • putatively bridging the actin-based cytoskeleton with an array of potential LIM protein-binding partners
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text regulation of actin reorganization by phosphorylation regulated mechanism
  • involved in axon guidance
  • PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F-actin
  • binary protein prtein interactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS