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FLASH GENE
Symbol CSNK1G2 contributors: npt - updated : 14-06-2002
HGNC name casein kinase 1, gamma 2
HGNC id 2455
Location 19p13.3      Physical location : 1.941.160 - 1.981.334
Synonym name
  • CKI-gamma 2
  • casein kinase I isoform gamma-2
  • Synonym symbol(s) CK1g2
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2921 47 415 - Shirogane (2005)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineadrenal gland   highly
    Nervousnerve   highly
    Reproductivemale systemtestis  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a channel proline-rich sequence
  • a SH3 domain
  • a characteristic CKSG signature at C terminus
  • conjugated PhosphoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CK1 Ser/Thr protein kinase family
  • casein kinase I subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • casein kinase 1, may be involved in signaling pathways downstream of RTKS
  • phosphorylates and modulates the functions of MTA1, and that these extranuclear effects of estrogen might have important implications in regulating the functions of MTA1 in mammary epithelial and cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with the SH3 domain of the adapter proteins NCK1 or NCK2
  • preferentially acidic proteins, broad specificity
  • bind to PER1 and to promote its degradation
  • MTA1-binding protein
  • cell & other
    REGULATION
    induced by estrogen that stimulates its activity , effectively blocked by a specific inhibitor of CKI
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS