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FLASH GENE
Symbol PSMB2 contributors: mct - updated : 03-03-2020
HGNC name proteasome (prosome, macropain) subunit, beta type, 2
HGNC id 9539
Location 1p34.3      Physical location : 36.068.739 - 36.107.143
Synonym name subunit HSC7-1
Synonym symbol(s) HC7-1
EC.number 3.4.25.1
DNA
TYPE functioning gene
STRUCTURE 41.98 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 4351 - 176 - 2018 29780166
6 - 4426 - 201 - 2018 29780166
5 - 4235 - 84 - 2018 29780166
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratoryrespiratory tractbronchiole    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveolar cell type 1 Homo sapiens
Respiratoryalveolar cell type 2 Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Psmb2
Homologene
FAMILY peptidase family T1b
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
  • has likely an active role in homologous recombination (HR) and DNA double-strand break (DSB) repair but does not alter the intracellular level of the RAD51
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NUDT21 inhibits hepatocellular carcinoma proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS