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FLASH GENE
Symbol PFKFB3 contributors: mct/npt - updated : 07-06-2016
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
HGNC id 8874
Location 10p15.1      Physical location : 6.186.842 - 6.277.505
Synonym name
  • fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
  • inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
  • 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
  • renal carcinoma antigen NY-REN-56
  • Synonym symbol(s) IPFK2, PFK2, PFK-2, FLJ37326
    EC.number 2.7.1.105, 3.1.3.46
    DNA
    TYPE functioning gene
    STRUCTURE 90.67 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure
  • promoter with TATA box, SP1 binding site, AP2 binding sites
  • regulatory motif for E.box, nuclear factor NF1 and progesterone response element
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text spliced into several variants that encode distinct carboxyl-terminal domains (Yalcin 2009)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4224 - 500 - Yalcin (2009)
    15 - 4553 - 520 - Yalcin (2009)
    - splicing - - - - Yalcin (2009)
  • localized to the nucleus (the residues required for nuclear trafficking reside in the carboxyl terminus)
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestivemouth   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
     kidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Connectivebone  moderately
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text placenta, embryonic tissue, umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a kinase domain at the N terminus
  • a phosphorylation sites for Camp dependent protein kinase
  • a biphosphatase domain at the C terminus
  • HOMOLOGY
    interspecies homolog to rattus Pfkfb3 (97.64 pc)
    homolog to murine Pfkfb3 (97.69 pc)
    Homologene
    FAMILY
  • phosphoglycerate mutase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized to the nucleus (Yalcin 2009)
    basic FUNCTION
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, bifunctional enzyme
  • involved in fructose 2,6-P2 synthesis and degradation
  • catalyzes the synthesis and degradation of fructose 2,6-bisphosphate (Fru-2,6-P2), a signaling molecule that controls the balance between glycolysis and gluconeogenesis in several cell types
  • crucial isozyme in supporting growing and proliferant cell metabolism
  • may have a function that is distinct from the regulation of glycolysis (Yalcin 2009)
  • having a rolein nuclear signaling (Yalcin 2009)
  • PRKAA1 and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • EDTA
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in solid tumors and leukemias (Yalcin 2009)
    constitutional     --over  
    in response to several mitogenic stimuli, including progesterone, serum, and insulin (Yalcin 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS