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FLASH GENE
Symbol NRAP contributors: npt/ - updated : 10-07-2008
HGNC name nebulin-related anchoring protein
HGNC id 7988
Location 10q25.3      Physical location : 115.348.583 - 115.423.805
Synonym symbol(s) N-RAP
DNA
TYPE functioning gene
STRUCTURE 75.22 kb     42 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
41 - 5417 193 1695 - Mohiddin (2003)
42 - 5522 197 1730 - Mohiddin (2003)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a LIM domain
  • HOMOLOGY
    interspecies ortholog to murine Nrap
    Homologene
    FAMILY
  • nebulin family of giant myofibrillar proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • helping anchor myofibril terminal actin filaments to the membrane
  • involved in actin filament organization and muscle contraction
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text muscle development, cell shape and cell size control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to actin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS