basic FUNCTION
| purinoceptor, P2X4, ionotropic class, receptor for ATP acting as a ligand gated ion channel |
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P2RX4 as well as P2RY12 is involved in ATP-induced microglial chemotaxis |
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potentially, retains its function within the degradative environment of the lysosome and can subsequently traffic out of lysosomes to upregulate its exposure at the cell surface and phagosome |
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ATP gated cation-selective channel, which can be upregulated following nerve injury or stimulation by various cytokines |
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specifically involved in inflammatory-mediated Prostaglandin E2 production and might therefore represent useful therapeutic targets |
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PANX1 hemichannels and P2RX1 and P2RX4 facilitate ATP release and autocrine feedback mechanisms that control Ca(2+) entry and T-cell activation at the immune synapse |
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calcium-permeable cation channels gated by extracellular ATP |
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involved in endothelium-dependent changes in large arterial tone in response to shear stress |