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FLASH GENE
Symbol MCHR1 contributors: mct/ - updated : 21-12-2011
HGNC name melanin-concentrating hormone receptor 1
HGNC id 4479
Location 22q13.3      Physical location : 41.075.181 - 41.078.817
Synonym name
  • G protein-coupled receptor 24
  • MCH receptor 1
  • G-protein coupled receptor 24
  • somatostatin receptor-like protein
  • Synonym symbol(s) SLC1, GPR24, MCH1R, MGC32129
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 3.64 kb     2 Exon(s)
    motif repetitive sequence
    text structure in its ORF
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2423 - 422 - 2006 16524757
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortexfrontal 
     braindiencephalonhypothalamus  
     brainmidbrain   
     brainhindbrainpons  
    Reproductivefemale systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • three consensus N glycosylation sites
  • a DRY motif (major contribution of the DRY motif in MCH1R is to govern receptor conformation and G protein coupling/recognition)
  • HOMOLOGY
    intraspecies homolog to stomatostatin-like receptor 1
    Homologene
    FAMILY
  • G protein coupled receptor (stomatostatin receptor) family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • G protein coupled receptor, involved in emotion, memory and sensory perception
  • mediating the effects of MCH (PMCH) on feeding
  • heptahelical integral membrane proteins
  • modulates orexigenic activity of MCH, the corresponding endogenous peptide agonist
  • plays a significant role in regulation of energy balance, food intake, physical activity and body weight
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral
    text neuronal regulation of food consumption
    PATHWAY
    metabolism energetic
    signaling hormonal , signal transduction
    inhibiting adenylate cyclase pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms (
  • cell & other
    REGULATION
    activated by PCMH
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pheochromocytomas, neuroblastomas and ganglioneuroblastomas
    constitutional     --other  
    DNA methylation at MCHR1 is allele-specific, age-dependent, BMI-associated and affects transcription
    Susceptibility
  • to juvenile-onset obesity
  • to bipolar affective disorder and schizophrenia
  • Variant & Polymorphism SNP
  • increasing the risk of juvenile-onset obesity
  • epigenetic regulation contributes to the age- and/or population specific effects reported for MCHR1 in several obesity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    antagonists of MCHR1 function will prove therapeutically useful as anti-obesity agents
    ANIMAL & CELL MODELS
  • lack of ciliary localization of somatostatin receptor type 3 (Sstr3) and melanin-concentrating hormone receptor 1 (Mchr1) in neurons from mice lacking the Bbs2 or Bbs4 gene (altered signaling caused by mislocalization of ciliary signaling proteins underlies the BBS phenotypes, providing a potential molecular mechanism to link cilia defects with obesity)