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FLASH GENE
Symbol HOXC4 contributors: mct - updated : 20-01-2016
HGNC name homeobox C4
HGNC id 5126
Location 12q13.3      Physical location : 54.410.641 - 54.449.813
Synonym name homeo box 3E
Synonym symbol(s) HOX3E, cp19, Hox-3E, HOX3
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
STRUCTURE 39.17 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D12S1651 - D12S325 - HOXC4 - D12S103 - HOXC4 - D12S312 - qter
Authors UCSC (2009)
Text see HOXC@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 splicing 2300 29.7 264 - Meazza (95)
  • encoding the same protein than variant 2
  • 2 splicing 1689 29.7 264 - Meazza (95)
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text first trimester trophoblast, anterior limb
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Antp-type hexapeptide motif
  • an homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to rattus Hoxc4 (99.2 pc)
    homolog to murine Hoxc4 (99.6 pc)
    Homologene
    FAMILY
  • antp homeobox family
  • deformed subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in a developmental regulatory system providing cells with specific positional identities on the anterior-posterior axis
  • playing a role in regulation of transcription
  • controling lymphocyte activation and/or proliferation (Meazza 95)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • anterior/posterior pattern formation
  • cartilage development
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to ATTT elements (SREs) in the Igamma and I epsilon promoters (Schaffer 2003)
    RNA
    small molecule
    protein
  • NFKB1 mediates TNFSF13-induced HOXC4 transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS