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FLASH GENE
Symbol DUSP7 contributors: - updated : 16-01-2004
HGNC name dual specificity phosphatase 7
HGNC id 3073
Location 3p21.1      Physical location : 52.082.938 - 52.090.461
Synonym name mitogen activated protein kinase (MAPK) phosphatase 7
Synonym symbol(s) MKPX, MKP-X, PYST2
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1107 40 368 - Nissembaum-Levy
  • 3exons,1,2,3b
  • CDC25 homologous region and DUSP catalytic domain
  • - - 555 20 - - Nissembaum-Levy
    one single exon,3(3a,3b),negative regulator of PYST2-L
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines malignant leukocyte cells lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two N terminal CH2 domains and an extended active site sequence motif conserved in dual specificity phosphatases
    HOMOLOGY
    Homologene
    FAMILY MAP-kinase phosphatases subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION may be involved in protein amino acid dephosphorylation.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS