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FLASH GENE
Symbol PSMD1 contributors: mct - updated : 10-07-2018
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
HGNC id 9554
Location 2q37.1      Physical location : 231.921.577 - 232.037.538
Synonym name
  • 26S proteasome regulatory subunit S1
  • 26S proteasome subunit p112
  • Synonym symbol(s) MGC133040, MGC133041, P112, S1, Rpn2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 115.96 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3329 - 953 - 2014 24910440
    24 - 3236 - 922 - 2014 24910440
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    ten PC repeats
    HOMOLOGY
    Homologene
    FAMILY proteasome subunit S1 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding
  • acting as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of
  • ubiquitinated proteins
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component 26 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • p112-L (105kDa) and p112-S (90kDa)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAPK14 negatively regulates the proteasome activity by phosphorylating Thr-273 of PSMD1
  • interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function
  • PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a biomarker for age-related macular degeneration
  • Therapy target
    ANIMAL & CELL MODELS