Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAGEA6 contributors: mct - updated : 20-05-2020
HGNC name melanoma antigen family A, 6
HGNC id 6804
Location Xq28      Physical location : 151.867.244 - 151.870.814
Synonym name
  • MAGE-6 antigen
  • cancer/testis antigen family 1, member 6
  • MAGE3B antigen
  • Synonym symbol(s) MAGE6, MAG6, MAGE3B, MAGE-3b, CT1.6, MGC52297
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.57 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1723 34 314 - 2019 31593956
    encoding the same protein as variant 2
    3 - 1787 34 314 - 2019 31593956
  • containing an additional segment in the 5' UTR, in the 2nd codon as compared to variant 1
  • encoding the same protein as variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Endocrineadrenal gland   highly
    Reproductivefemale systemplacenta  highly
     female systemuteruscervix moderately
     male systemtestis   
     male systemprostate  moderately
    Skin/Tegumentskin   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines in many tumor cell lines (melanoma, lung, breast)
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA12/MAGEA2
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    text
  • MAGEA3, MAGEA4, MAGEA6,MAGEA8, are expressed in the undifferentiated human embryonic stem (hES) cells and early differentiated embryoid bodies (EBs) cells
  • basic FUNCTION
  • may play a role in tumor transformation or aspects of tumor progression
  • the frequencies of EPHA2 and MAGE6A-specific CD4+ T cells in cancerous patients were significantly correlated with active disease (AD) and gender of the patient (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant expression patterns of MAGEA6, in teratocarcinoma cells can be considered as specific teratocarcinoma biomarkers promoted the malignant phenotype
  • Therapy target
    ANIMAL & CELL MODELS