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FLASH GENE
Symbol MAGEA12 contributors: mct/npt - updated : 25-09-2009
HGNC name melanoma antigen family A, 12
HGNC id 6799
Location Xq28      Physical location : 151.899.298 - 151.903.184
Synonym name
  • cancer/testis antigen family 1, member 12
  • MAGE-12 antigen
  • MAGE12F antigen
    • Synonym symbol(s) MAGE12, MAGC, CT1.12
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.88 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1666 34.7 314 - Wischnewski (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland   moderately
    Reproductivemale systemtestis   
    Skin/Tegumentskin   predominantly
    cell lineage
    cell lines various tumors cell lines (melanoma, lung, breast)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
    • HOMOLOGY
    intraspecies homolog to MAGEA6/MAGEA3
    Homologene
    FAMILY
  • MAGE family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in tumor transformation or aspects of tumor progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MBD2 (up-regulate the basal activity of the promoter of MAGE proteins) (Wischniewski 2007)
    repressed by the TRD of MBD1 and MECP2 (Wischnewski 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary breast cancer in progression
    tumoral     --over  
    in oral squamous cell carcinoma (Mollaoglu 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS