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FLASH GENE
Symbol BLZF1 contributors: mct - updated : 04-02-2014
HGNC name basic leucine zipper nuclear factor 1 (JEM-1)
HGNC id 1065
Location 1q24.2      Physical location : 169.337.193 - 169.365.778
Synonym name
  • JEM-1short protein
  • Synonym symbol(s) JEM1, GOLGIN-45, JEM-1, JEM-1s, MGC22497
    DNA
    TYPE functioning gene
    STRUCTURE 28.59 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D1S196 - D1S431 - D1S445 - D1S2658 - SELE - BLZF1 - D1S433 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2344 45 400 ubiquitous 1997 9129147
  • JEM1L
  • - polyA site 1300 23 174 cytoplasmic 1997 9129147
    extension exon 3 and P
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine repeat domain, interacting in the nucleus with AP1 (activator protein 1)
  • a PEST motif and several phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • basic leucine zipper protein nuclear transcription factor, involved in the transcription regulation from POLR2 promoter
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with GORASP2 form a RAB2A effector complex on medial-Golgi essential for normal protein transport and Golgi structure
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BLZF1 and CASC3 are further substrates targeted by tankyrase and RNF146 for degradation
  • with BLZF1 and ARHGEF28, LURAP1 bind MYO18A
  • cell & other
    REGULATION
    Other upregulated during retinoid-induced maturation of NB4-promyelocytic leukemia cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS