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FLASH GENE
Symbol GMPS contributors: npt/mct - updated : 10-01-2009
HGNC name guanine monophosphate synthetase
HGNC id 4378
Location 3q24      Physical location : 155.588.324 - 155.655.518
Synonym name
  • glutamine amino transferase
  • GMP synthase [glutamine-hydrolyzing]
  • glutamine amidotransferase
  • guanosine 5'-monophosphate synthase
  • glutamine-hydrolyzing
  • MLL/GMPS fusion protein
  • Synonym symbol(s) D3S4088, GMPS-PEN
    EC.number 6.3.5.2
    DNA
    TYPE functioning gene
    STRUCTURE 6.72 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2457 76.7 693 - Pegram (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     spinal cord   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal glutamine amidotransferase (GAT)
  • GMP synthase C terminal domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans m106.4
    Homologene
    FAMILY
  • glutamine amidotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis
  • USP7-GMPS complex catalyzed the selective deubiquitylation of histone H2B, but not H2A
  • can regulate the activity of a ubiquitin protease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component complexing with USP7
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    wiyh MLL in t(3;11)(q25;q23)in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS