Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TSG10A contributors: npt - updated : 14-12-2009
Location 10q23.-q26      Physical location : -
Genatlas name chromosome 10, bladder
DNA
TYPE functioning gene
MAPPING cloned   linked   status confirmed
Map cen - ((D10S569 - D10S219 - D10S1667 - D10S201 - D10S1777 - D10S1644 - D10S1698 )) - D10S1687 - D10S532 - D10S579 - D10S215 - ((D10S541 - D10S1739 - D10S564 - D10S2141 - D10S583 )) - [D10S536 - D10S185 - PTEN - D10S571 - D10S574 - D10S198 - D10S202 - D10S603 - D10S622 - D10S192 - D10S1268 - D10S108 - D10S566 - D10S205 ] - D10S597 - qter
Authors Li (97), Cappellen (97), Steck (98), Tsuchiya (98), Yeh (99)
Text (LOH in glioblastoma, prostate carcinoma, endometrial cancer), {minimal LOH regions in muscle aggressive bladder carcinoma}, ((follicular thyroid adenomas))
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • tumor suppressor gene(s)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    del 10q22.3-q24.1 in juvenile polyposis
    tumoral   LOH    
    in chromophobe renal cell carcinoma metastatic
    tumoral   LOH    
    bladder, breast carcinoma, follicullar thyroid adenomas, melanoma, endometrial, prostate metastatic in progression
    tumoral   deletion    
    in squamous cell carcinoma of the lung (metastatic), invasive primary glioblastoma, juvenile polyposis, malignant meningioma (progression) Cowden (CWD/PTEN) and in Bannayan-Riley-Ruvalcaba or Bannayan Zonana region (see also TSG10B)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS