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FLASH GENE
Symbol RPL19 contributors: mct - updated : 30-11-2022
HGNC name ribosomal protein L19
HGNC id 10312
Location 17q12      Physical location : 37.356.535 - 37.360.980
Synonym name
  • 60S ribosomal protein L19
  • ribosomal protein L19, cytosolic, N-terminus truncated
  • Synonym symbol(s) FLJ27452, MGC71997, DKFZp779D216
    EC.number 6.3.5.5
    DNA
    TYPE functioning gene
    STRUCTURE 4.45 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 737 - 196 - 1995 7789970
    6 - 1097 - 194 - 1995 7789970
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     pharynx   highly
    Hearing/Equilibriumearinnercochlea highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver at the early pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Rpl19
    Homologene
    FAMILY L19E family of ribosomal proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • encodes a ribosomal protein that is a component of the 60S subunit
  • RPL19 may play an important role in promoting tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPL19 regulates TLR3 signaling, which is cell type specific and may be involved in pathogenesis of autoimmune diseases and chronic inflammatory diseases
  • ERH is likely localizing to the nucleus through binding to one of its DNA-binding partners, such as RPS3 or RPL19
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells by amplification and copy number variation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpression of RPL19 predicted a poor prognosis in hepatocellular carcinoma (HCC)
  • expression of RPL19 could be a valuable marker in prostate cancer diagnosis and patient management
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may serve as a promising therapeutic target for treatment of HCC
    ANIMAL & CELL MODELS