Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SCG2 contributors: mct - updated : 16-10-2012
HGNC name secretogranin II (chromogranin C)
HGNC id 10575
Location 2q36.1      Physical location : 224.461.659 - 224.467.217
Genatlas name manserin
Synonym name
  • EM66 precursor
  • manserin
  • Synonym symbol(s) CHGC, SG2
    DNA
    TYPE functioning gene
    STRUCTURE 5.56 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site   cAMP
    text structure consensus TATA box and cyclic AMP response element
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2586 - 617 - 2000 10648883
    - - - - 40 not only the brain but also the endocrine system such as the pituitary and adrenal glands, suggesting its role in the endocrine system 2010 20495819
  • neuropeptide derived from secretogranin II
  • occurring in the endocrine pancreas, may have a potential role in the endocrine system
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     neuroendocrinepituitary  highly
    Nervousbrainhindbraincerebellum highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text adrenal gland
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
    acidic protein of secretory granules
    HOMOLOGY
    interspecies homolog to murine Scg2
    Homologene
    FAMILY chromogranin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in the packaging of sorting of peptide hormones and neuropeptider into secretory vesides
  • exerting a specific role in the neuroendocrine system
  • represents a key AP1-regulated protein that counteracts Nitric oxide toxicity and mediates neuronal differentiation of neuroblastoma cells
  • SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • aggregating in its presence,granin family,including a conserved peptide EM66 posttranslationally processed from CHGC in the adrenals,marker for neuronal differentiation in neuroblastoma cell lines
  • SCG2 interacts with SCG3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased in patients with chronic, stable heart failure
    tumoral     --over  
    in endocrine pancreatic tumors with higher concentrations than patients with carcinoid tumors or pheochromocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a new cardiac biomarker
  • Therapy target
    ANIMAL & CELL MODELS