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FLASH GENE
Symbol BST1 contributors: mct - updated : 09-01-2018
HGNC name bone marrow stromal cell antigen 1
HGNC id 1118
Location 4p15.33      Physical location : 15.704.572 - 15.733.795
Synonym name
  • ADP-ribosyl cyclase 2
  • CD157 antigen
  • cADPr hydrolase 2
  • cyclic ADP-ribose hydrolase 2
  • Synonym symbol(s) CD157, BST-1
    EC.number 3.2.2.6
    DNA
    TYPE functioning gene
    STRUCTURE 29.22 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1497 42 318 - 2017 29162908
    10 - - - 333 in human neutrophils 2017 29162908
  • includes an unreported exon, exon 1b, located between exons 1 and 2 of BST1
  • exon 1b is a genomic innovation acquired during primate evolution, pointing to the importance of alternative splicing for CD157 function
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeanterior segmentcornea   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    Blood/Hematopoieticneutrophil Homo sapiens
    Visualepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • glycosyl-phosphatidylinositol-anchored protein (ecto NADase gene)
  • conjugated GlycoP
    HOMOLOGY
    intraspecies paralog to CD38
    Homologene
    FAMILY
  • ADP-ribosyl cyclase family
  • CATEGORY enzyme , regulatory , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in pre-B-cell growth
  • important mediator of neutrophil adhesion and migration
  • GPI-anchored cell surface glycoprotein, physically interacts with ITGAM complex in human neutrophils
  • with CD38, are NAD(+)-consuming ectoenzymes and surface receptors
  • catalyses formation of cyclic ADP-ribose (cADPR), mobilizing calcium (Ca2+) from ryanodine-sensitive intracellullar Ca2+ stores in the endoplasmic reticulum (Satake 2009)
  • acts as a molecular organizer of signaling-competent membrane microdomains and that it forms part of a larger molecular machine ruled by integrins
  • implicated in the progression of Epithelial ovarian carcinoma (EOC) to metastatic disease
  • central role of BST1 in cell-extracellular matrix interactions
  • catalyzes the hydrolysis of nicotinamide riboside (NR) and nicotinic acid riboside (NAR)
  • may play a role in the embryonic and adult nervous systems
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel SCRG1/BST1 axis determines the fate of mesenchymal stem cells (hMSCs) by regulating their kinetic and differentiation potentials
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BST1 binds FN1 with high affinity within its heparin-binding domains 1 and 2
  • SCRG1 secreted from mesenchymal stem cells (MSCs) and its receptor BST1 are positive regulators of stem cell qualities such as self&
  • 8209;renewal, migration abilities, and osteogenic differentiation potential
  • interacts with extracellular matrix components and regulates leukocyte diapedesis via integrin-mediated signalling in inflammation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is negatively correlated with epithelial ovarian cancer outcome in patients
    Susceptibility
  • to Parkinson disease
  • to autism spectrum disorder
  • Variant & Polymorphism SNP
  • four SNPs (rs11931532, rs12645693, rs4698412 and rs4538475) strongly associated with Parkinson disease
  • BST1 gene single nucleotide polymorphisms are associated with autism spectrum disorder
  • Candidate gene
    Marker potential marker of corneal limbal cells in the stem cell niche
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    attractive therapeutic target in inflammation and cancer
    cancerreproductiveovary
    may represent a valuable therapeutic target
    ANIMAL & CELL MODELS