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FLASH GENE
Symbol CRISP1 contributors: mct - updated : 18-10-2017
HGNC name cysteine-rich secretory protein 1
HGNC id 304
Location 6p12.3      Physical location : 49.801.978 - 49.834.218
Synonym name
  • protein DE-like
  • AEG-related protein
  • acidic epididymal glycoprotein-like 1
  • cysteine-rich secretory protein-1 delta
  • Synonym symbol(s) CRISP-1, ARP, HUMARP, HSCRISP1D, HSCRISP1G, AEGL1
    DNA
    TYPE functioning gene
    STRUCTURE 32.25 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1892 28.5 249 - 1996 8665901
    7 splicing 1803 20.5 178 - 1996 8665901
    lacking an exon in the coding region which results in a frameshift and an early stop codon
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemmale genital tractepididymis   Homo sapiens
     male systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepididymal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal CAP domain
  • a C-terminal 12 AAs region corresponding to an evolutionary conserved motif of the CRISP family, named signature 2 (S2), required for egg-binding ability
  • HOMOLOGY
    interspecies homolog to C.elegans T05A10.5
    ortholog to murine Crisp4
    Homologene
    FAMILY
  • cysteine-rich secretory protein (CRISP) family
  • family grouping mammalian SCP/TPX1,insects AG3/AG5, fungi SC7/SC14 and plants PR-1
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text secreted into the epididymal lumen
    basic FUNCTION
  • playing a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface and maturation
  • epididymal protein thought to participate in gamete fusion through its binding to egg-complementary sites
  • appears to be involved in the first step of sperm binding to the zona pellucida, identifying a novel role for this protein in fertilization
  • player in the mammalian fertilization process
  • CRISP1 stimulates sperm orientation by modulating sperm hyperactivation, a vigorous motility required for penetration of the egg vestments
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP1 and CRISP2 interact with common egg surface binding sites suggesting a functional cooperation between CRISP1 and CRISP2 to ensure the success of fertilization
  • CRISP1 is a multifunctional protein involved not only in sperm-egg fusion but also in the previous stage of sperm-ZP binding through its specific interaction with human ZP3
  • CRISP1 has the ability to regulate CATSPER1, the principal sperm Ca(2+) channel involved in hyperactivation and essential for fertility
  • cell & other
  • binding to the postacrosomal region of the sperm head
  • REGULATION
    Other regulated by androgen.
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene likely candidate for immunocontraception
    Marker
    Therapy target
    ANIMAL & CELL MODELS