basic FUNCTION
| likely involved in active cell migration |
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promoting the exchange of GDP by GTP |
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with PTPRF, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth |
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TRIO acts as a major regulator of cytokinesis, cell migration, axon outgrowth, axon guidance, and dendritic arborization and plays a role in synaptogenesis by modulating excitatory synaptic transmission |
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activated the IKK activity by binding with the IkappaB kinase (IKK) complex |
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Rho-specific guanine nucleotide exchange factor, activates NF-kappaB via physical association with IkappaB kinase complexes |
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GEF TRIO is responsible for lamellipodia formation through its N-terminal DH-PH domain in a RAC1-dependent manner during fibronectin-mediated spreading and migration |
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ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis |
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upon clustering of ICAM1, the Rho-guanine nucleotide exchange factor TRIO activates RAC1, prior to activating RHOG, in a filamin-dependent manner |
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promotes leukocyte transendothelial migration by inducing endothelial docking structure formation in a filamin-dependent manner through the activation of RAC1 and RHOG |
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crucial role for the Rho-GEF TRIO in stabilizing junctions based around vascular endothelial (VE)-cadherin (also known as CDH5) |
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importance of spatio-temporal regulation of the actin cytoskeleton through TRIO and RAC1 at CDH5-based cell-cell junctions in the maintenance of the endothelial barrier |