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FLASH GENE
Symbol CCL11 contributors: mct - updated : 18-06-2020
HGNC name chemokine (C-C motif) ligand 11
HGNC id 10610
Location 17q12      Physical location : 32.612.686 - 32.615.199
Synonym name
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
  • eotaxin
  • eosinophil chemotactic protein
  • Synonym symbol(s) SCYA11, MGC22554, EOTA
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.59 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1005 - 97 - 2019 30583236
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systemuterus   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Ccl11
    homolog to rattus scya11
    Homologene
    FAMILY intercrine beta family
    CATEGORY adhesion , signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • eosinophil, basophil and dendritic cell, chemoattractant
  • putatively involved in eosinophil trafficking and other CCR3 mediated biological phenomena
  • involved in T lymphocyte
  • activation in the processus of allergy
  • ligand of CCR3
  • CCL26, CCL24, CCL11 have the ability to regulate extravillous trophoblast (EVT) functions critical to their role in vessel remodelling, suggesting a new role for the eotaxin group of chemokines during placentation
  • CCL11, CCL24, and CCL26 are chemokines involved in the recruitment of eosinophils into tissues and that mainly activate CCR3
  • blood-borne CCL11 may have important physiologic functions in the CNS and implicates the blood-brain barrier (BBB) as an important regulator of physiologic versus pathologic effects of CCL11
  • is crucial in eosinophil chemoattraction and activation in asthma pathogenesis
  • CCL11, CCL24, and CCL26 all showed potent bactericidal activity, mediated through membrane disruption, against the airway pathogens Streptococcus pneumoniae, Staphylococcus aureus, Nontypeable Haemophilus influenzae, and Pseudomonas aeruginosa
  • eotaxins can contribute to host defense against common airway pathogens and that their activities are modulated by mast cell proteases
  • levels of CCL11 in plasma and CSF increase with age, and CCL11 suppresses adult neurogenesis in the central nervous system (CNS), resulting in memory impairment
  • role of CCL11 in osteoclast migration and resorption
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CCR2 (antagonist) and CCR5 (agonist)
  • SOCS1 and SOCS3 exhibit enhanced adhesion and reduced migration towards the chemokine CCL11
  • CCR3, an important receptor for CCL11, did not facilitate CCL11 transport across the BBB, although high concentrations of a CCR3 inhibitor increased brain uptake without causing BBB disruption
  • CCL11 significantly promoted the migration of microglia, and induced microglial production of reactive oxygen species by upregulating nicotinamide adenine dinucleotide phosphate-oxidase 1 (NOX1)
  • cell & other
    REGULATION
    induced by TNF-alpha
    interleukin-1 alpha
    interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in bullous pemphigoid
    constitutional       gain of function
    is associated with fibrotic progression of primary biliary cholangitis
    constitutional     --over  
    in the brain and cerebrospinal fluid (CSF) in chronic traumatic encephalopathy (CTE)
    constitutional     --over  
    in the sera and cerebrospinal fluids (CSF) of patients with neuroinflammatory disorders, including multiple sclerosis
    constitutional     --over  
    serum CCL11, CCL24 and CCL26 are upregulated in primary biliary cholangitis but CCL11 and CCL26 are associated with fibrotic progression
    Susceptibility to asthma, serum total IgE
    Variant & Polymorphism SNP
  • polymorphisms in eotaxin gene family associated with asthma, IgE, and eosinophil
  • a hexanucleotide repeat associated with asthma serum total IgE and plasma eotaxin
  • Candidate gene
    Marker
  • is a potentially useful biomarker for the diagnosis and assessment of asthma severity and control, especially in sputum
  • CCL11 may be a novel target for future chronic traumatic encephalopathy (CTE) biomarker studies
  • Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    CCL11/CCR3 pathway could be a new target for treatment of inflammatory bone resorption
    ANIMAL & CELL MODELS