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FLASH GENE
Symbol RPL18 contributors: mct - updated : 26-12-2022
HGNC name ribosomal protein L18
HGNC id 10310
Corresponding disease
DBA18 Diamond-Blackfan anemia 18
Location 19q13.33      Physical location : 49.118.587 - 49.122.433
Synonym symbol(s) DBA18, L18, FLJ33938
DNA
TYPE functioning gene
STRUCTURE 3.85 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - RPS16 - RPS19 - RPL18 - RPL13A - RPS11 - RPS5 - RPL28 - RPS9 - qter
Authors Uechi (01)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 556 - 159 - 2015 26092250
7 - 643 - 188 - 2015 26092250
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines Hela cell
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus,nucleolus
basic FUNCTION
  • 60S ribosomal protein L18
  • RPL18 is required during DENV (dengue virus) replicative cycle
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of ribosome,large subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • SNRPD3 regulate likely spliceosome and ribosome subunit expression levels and controlled spliceosome and ribosome function via RPL18
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA18
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    promoted senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable molecular biomarker for the diagnosis of prostate carcinoma
  • could serve as potential biomarkers of clear cell renal cell carcinoma (ccRCC)
  • Therapy target
    ANIMAL & CELL MODELS