basic FUNCTION
| involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus |
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involved in mechanical-force-dependent facilitation of actin polymerization at focal adhesions |
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may play an important role in the organization of focal adhesions with LASP1 and NEBL |
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required for the reorganization of actin fibers and migration of the endocardial cells (reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT) |
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possible ZYX functions in morphogenetic rearrangements, maintaining collective migration by transducing individual cells' movements through adherens junctions, thus preventing the dissociation of individual migratory cells |
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ZYX mediation of stretch-induced gene expression in human endothelial cells |
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key regulator of actin assembly because zyxin recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly |
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having tumor suppressor activity in Ewing tumor cells |
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actin regulatory protein that is concentrated at sites of actin–membrane association, particularly cell junctions |
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novel regulator of the HIPK2-TP53 signaling axis in response to DNA damage |
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potential role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-TP53 signaling axis |
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is a regulator of Hippo signaling, thus also raising the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling |
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focal adhesion protein that responds to external mechanical forces |
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stabilizes DHX58 and MAVS interactions and promotes type I interferon response |