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FLASH GENE
Symbol ZYX contributors: mct - updated : 22-02-2017
HGNC name zyxin
HGNC id 13200
Location 7q34      Physical location : 143.078.359 - 143.088.202
Synonym name
  • component of cell junction matrix,concentrated at adhesion plaques and along actin-filament bundles
  • zyxin-2
  • Synonym symbol(s) ESP-2, HED-2
    DNA
    TYPE functioning gene
    STRUCTURE 9.85 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2325 - 572 - 2005 15748890
    10 - 2322 - 572 - 2005 15748890
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal proline rich region
  • a nuclear export signal
  • a LIM domain region playing a major role in regulating zyxin function in cell–cell adhesion, and acting as a negative regulatory element in controlling zyxin function , and localizes to cell–cell adhesion via AAs 230–280 of the central hinge region
  • three C terminal cysteine-rich LIM/double zinc finger motifs, recruiting zyxin to force-bearing sites at the leading edge of migrating cells
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • zyxin/ajuba family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • colocalizes with HIPK2 at the cytoskeleton and in the cell nucleus
  • localizes to the sites of cell-cell adhesion and is thought to promote actin assembly with ENAH/VASP
  • basic FUNCTION
  • involved in the spatial control of actin assembly and in communication between the adhesive membrane and the cell nucleus
  • involved in mechanical-force-dependent facilitation of actin polymerization at focal adhesions
  • may play an important role in the organization of focal adhesions with LASP1 and NEBL
  • required for the reorganization of actin fibers and migration of the endocardial cells (reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT)
  • possible ZYX functions in morphogenetic rearrangements, maintaining collective migration by transducing individual cells' movements through adherens junctions, thus preventing the dissociation of individual migratory cells
  • ZYX mediation of stretch-induced gene expression in human endothelial cells
  • key regulator of actin assembly because zyxin recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • having tumor suppressor activity in Ewing tumor cells
  • actin regulatory protein that is concentrated at sites of actin–membrane association, particularly cell junctions
  • novel regulator of the HIPK2-TP53 signaling axis in response to DNA damage
  • potential role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-TP53 signaling axis
  • is a regulator of Hippo signaling, thus also raising the possibility that mechanical strain could be linked to the regulation of gene expression and growth through Hippo signaling
  • focal adhesion protein that responds to external mechanical forces
  • stabilizes DHX58 and MAVS interactions and promotes type I interferon response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • zyxin constituent of cell junction matrix
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NEBL and LASP1 (SH3 domains from LASP1 and nebulin can also interact with zyxin, but the SH3 domains from more distantly related proteins such as vinexin and SNX9 do not)
  • interaction partner for synemin
  • by recruiting VASP, zyxin regulates actin assembly at the sites of force-bearing cell-cell adhesion
  • participates in regulation of actin dynamics by binding to VASP, an interaction that occurs through a series of four proline-rich repeats at the N-terminus of the zyxin sequence
  • ZYX–PVRL2 interaction plays a critical role in zyxin targeting to these sites
  • novel functional target and effector of TGFB signaling in lung cancer
  • ZYX serves as a scaffold for the interactions between DHX58 and MAVS
  • ZYX promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP1 activation
  • cell & other
    REGULATION
    activated by in the nucleus by thymosin beta4 (TMSB4X)
    Other zyxin phosphorylation prevents zyxin head–tail and suggests how the loss of the regulatory head–tail interaction alters zyxin function at cell–cell junctions
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    LIM-domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo