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FLASH GENE
Symbol STC1 contributors: mct/npt/pgu - updated : 06-08-2016
HGNC name stanniocalcin 1
HGNC id 11373
Location 8p21.2      Physical location : 23.699.433 - 23.712.320
Synonym symbol(s) STC, STC-1
DNA
TYPE functioning gene
STRUCTURE 12.89 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure
  • HIF-1A binding motif in human STC1 gene promoter
  • MAPPING cloned Y linked N status confirmed
    Map pter - D8S505 - STC1 - D8S298 - D8S131 - D8S339 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3897 - 247 - 2007 17032941
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinethyroid    
    Reproductivefemale systemovary  predominantly Homo sapiens
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidneynephron  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal, pregnancy
    Text highly in pregnancy and lactation
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a motif containing a cysteine–serine dipeptide, which binds both ferrous (Fe2+) and ferric (Fe3+) heme, and with Cys114 being indispensible for binding
  • conjugated PhosphoP , Other
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Stc
    intraspecies paralog to STC2
    Homologene
    FAMILY
  • stanniocalcin family
  • CATEGORY regulatory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative regulator of mineral phosphate homeostasis, likely by stimulation of phosphate uptake by the renal tubule
  • role in reproduction
  • could effectively prevent cytosolic Ca(2+) overload and protect cardiomyocytes from pathophysiological conditions such as in the failing heart
  • pro-apoptotic factor
  • regulates endothelial gene expression and modulates transendothelial migration of leukocytes, playing a critical role in transendothelial migration of inflammatory cells and being involved in the regulation of numerous aspects of endothelial function
  • STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress
  • key regulator of superoxide generation in macrophages, suggesting that STC1 may profoundly affect the immune/inflammatory response
  • modulator or purinergic receptor signaling
  • promotes the expression of VEGF, and VEGF subsequently enhances tumor angiogenesis which in turn promotes the gastric tumor growth
  • endocrine regulator of gill Ca(2+) uptake during hypercalcemia
  • STC1, STC2 are known to be involved in tumor progression and metastasis
  • STC1 and STC2 play positive roles in angiogenic sprouting
  • is a proteinase inhibitor, suggesting a previously unrecognized function of STC1 in the IGF system
  • high expression level of STC1 in M1-polarized cells may serve as a negative mediator in inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism metal
    signaling
    mineral
    a component
  • 56 kDa homodimeric glycoprotein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • known regulator of angiogenesis, and target gene of WNT2 signaling in HUVEC down-regulated by WNT2 treatment
  • STC1 Cys114 is essential for hemin binding (heme bound to STC1 may have an impact on the redox balance of the cell, which becomes more evident under oxidative stress)
  • presence of native complexes between PAPPA and STC1, STC2 in the human ovary, indicating STC-mediated PAPPA proteolytic inhibition
  • STC1 may serve as a negative mediator to regulate inflammation, which might be associated with the expression of TBC1D3
  • cell & other
    REGULATION
    activated by histone hyper-acetylation and the recruitment of activated NFkappaB
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in primary breast tumor (with BRCA1)
    tumoral     --over  
    in ovarian cancer tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer
  • Therapy target
    ANIMAL & CELL MODELS