Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NDUFA1 | contributors: mct - updated : 04-07-2009 |
HGNC name | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa |
HGNC id | 7683 |
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Corresponding disease |
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Location | Xq24 Physical location : 119.005.733 - 119.010.628 | ||
Synonym symbol(s) | MWFE, CI-MWFE, ZNF183 | ||
EC.number | 1.6.5.3 |
DNA |
TYPE | like-sequence |
STRUCTURE | 4.90 kb 3 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to bovine MWFE (subunit of complex I essential for an active complex I) |
Homologene |
FAMILY |
CATEGORY | enzyme , transport |
SUBCELLULAR LOCALIZATION
| intracellular |
intracellular,cytoplasm,organelle,mitochondria,inner | |
intracellular,cytoplasm,organelle,membrane | |
text | inner membrane, matrix side |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | electron transport |
PATHWAY |
metabolism | energetic |
signaling |
a component | component alpha 1, hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS) |
INTERACTION |
DNA |
RNA |
small molecule |
protein | interact with various mtDNA encoded complex I subunits (Potluri 2009) |
cell & other |
REGULATION |
activated by | thyroid hormones |
ASSOCIATED DISORDERS |
corresponding disease(s) | NDUFA1D |
related resource | MITOP database |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |