protein
| binding of arrestin-3 to the lutropin receptor (LHCGR) is dependent mostly on receptor activation rather than on phosphorylation |
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mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21 |
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association with the follitropin receptor (FSHR) depends on receptor activation and phosphorylation |
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OPRL1 function may be regulated by ADRBK2 phosphorylation of Ser-363 and ARR3 |
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ARR3 is required for OPRL1 activation of JNK signaling |
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binds MAPK10, MAP2K4, and MAP3K5, and promote MAPK10 activation |
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directly binds MAP2K7 |
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MAP2K4 and MAP2K7 compete for ARR3 binding |
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ARR3 promotes MAPK10 phosphorylation by MAP2K7 |
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ARR3 regulates the activity of multiple JNK isoforms, suggesting that it might play a role in survival and apoptosis of all cell types 4) |
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MAPK10 interacts with the non-receptor-binding side of ARR3 |
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MEF2D is required for the expression of various genes in photoreceptor and bipolar cells, including ARR3, GUCA1B, PDE6H and CACNA1S, which encode outer segment and synapse proteins |
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interact with hundreds of different G protein-coupled receptors (GPCRs), but by introducing mutations into elements that directly bind receptors, the specificity of ARR3 can be altered |