basic FUNCTION
| heparin-binding protein, with mitogenic activity for fibroblasts |
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playing an important role in the development or progression of hepatocellular carcinoma |
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transcriptional repressor, exerting its transcription repressive effect through binding to a conserved DNA element in the promoter of target genes |
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involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase and a regulation of this protein by phosphorylation in the nucleus |
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may play a critical role in the pathobiology of lung cancer through its mitogenic and angiogenic activities |
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having both mitogenic and angiogenic activity and is highly expressed in the developing heart and vasculature |
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involved in cell growth, cell invasion, and apoptosis. |
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nuclear protein that is a mitogen for a wide variety of cells |
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could function as a transcriptional repressor |
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functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CTBP1, CTBP2 |
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secreted heparin-binding growth factor that has been implicated in cancer development and progression |
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its over-expression may exert a prognostic role for tumour metastasis and recurrence in breast cancer by modulating epithelial-mesenchymal transition |
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is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis |
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novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer |
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involved in ribosome processing, protein synthesis, cell cycle and cell proliferation |
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plays a substantial role in Bladder cancer and promotes tumor development and progression by regulating the PI3K-AKT signaling pathway |