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FLASH GENE
Symbol HDGF contributors: mct/npt/pgu - updated : 24-06-2020
HGNC name hepatoma-derived growth factor (high-mobility group protein 1-like)
HGNC id 4856
Location 1q23.1      Physical location : 156.711.899 - 156.722.240
Synonym name
  • high-mobility group protein 1-like 2
  • hepatoma-derived growth factor
  • Synonym symbol(s) HMG1L2, RP11-66D17.10, DKFZp686J1764, FLJ96580
    DNA
    TYPE functioning gene
    STRUCTURE 10.34 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2397 27 240 is located inside of exosomes 2017 27926477
  • HDGFA
  • 6 - 2183 25.4 233 found exclusively on the outer surface 2017 27926477
  • HDGFC
  • involved in different cellular processes than HDGFA
  • 6 - 2208 28 256 found exclusively on the outer surface 2017 27926477
  • HDGFB
  • involved in different cellular processes than HDGFA
  • 6 - 2217 - 263 - 2017 27926477
    7 - 2198 - 208 - 2017 27926477
    6 - 2033 - 208 - 2017 27926477
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain   highly
    Reproductivemale systemtestis  predominantly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal PWWP domain required for the DNA binding
  • a putative nuclear localization signal (NLS)
  • a C terminal acidic region, without any apparent HGM motif
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • HDGF family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • ZEB1 interacts with hepatoma-derived growth factor (HDGF) and co-localizes in the nucleus
  • basic FUNCTION
  • heparin-binding protein, with mitogenic activity for fibroblasts
  • playing an important role in the development or progression of hepatocellular carcinoma
  • transcriptional repressor, exerting its transcription repressive effect through binding to a conserved DNA element in the promoter of target genes
  • involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase and a regulation of this protein by phosphorylation in the nucleus
  • may play a critical role in the pathobiology of lung cancer through its mitogenic and angiogenic activities
  • having both mitogenic and angiogenic activity and is highly expressed in the developing heart and vasculature
  • involved in cell growth, cell invasion, and apoptosis.
  • nuclear protein that is a mitogen for a wide variety of cells
  • could function as a transcriptional repressor
  • functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CTBP1, CTBP2
  • secreted heparin-binding growth factor that has been implicated in cancer development and progression
  • its over-expression may exert a prognostic role for tumour metastasis and recurrence in breast cancer by modulating epithelial-mesenchymal transition
  • is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis
  • novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer
  • involved in ribosome processing, protein synthesis, cell cycle and cell proliferation
  • plays a substantial role in Bladder cancer and promotes tumor development and progression by regulating the PI3K-AKT signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a transcriptional complex with CTBP1and CTBP2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • repressed SMYD1 gene transcription through interaction with a transcriptional corepressor C-terminal binding proteins CTBP1, CTBP2
  • critical target for transcriptional repression by the tumor suppressor TP53
  • interaction of HDGF and nucleolin (expression of a cytosolic variant of HDGF causes a redistribution of nucleolin into the cytoplasm)
  • PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with RRNAD1, HDGF and PRCC
  • ZEB1 interacts with hepatoma-derived growth factor (HDGF) and co-localizes in the nucleus
  • ZEB1 positively correlates with HDGF expression, and co-expression of ZEB1 and HDGF promotes the pathogenesis of endometrial carcinoma (EC)
  • cell & other
    REGULATION
    Other cell cycle regulated phosphorylation of HDGF may play an important role in vascular cell proliferation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer and its expression is correlated with poor prognosis of cancer
    tumoral     --over  
    in primary gastric, breast, and lung cancer tissues harboring mutant TP53 genes
    constitutional     --over  
    in the dermis of keloid compared with normal skin tissue
    tumoral     --over  
    in bladder cancer (BCa) and positively correlated with poor prognosis in patients
    tumoral     --over  
    is a potential unfavorable factor for the progression and prognosis of endometrial carcinoma (EC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene prognostic factor for gastrointestinal stromal tumors patients
    Marker
  • HDGF may constitute a novel diagnostic marker and therapeutic target for Helicobacter pylori (Hp)-induced gastritis and carcinogenesis
  • Therapy target potential target for cancer therapy
    SystemTypeDisorderPubmed
    cancerurinary 
    promising target for Bladder cancer treatment
    cancerdigestivestomach
    therapeutic target for Hp-induced gastritis and carcinogenesis
    ANIMAL & CELL MODELS