Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | POLA1 | contributors: mct/npt - updated : 11-06-2019 |
HGNC name | polymerase (DNA directed), alpha 1, catalytic subunit |
HGNC id | 9173 |
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Corresponding disease |
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Location | Xp22.11 Physical location : 24.712.063 - 25.015.100 | ||||
Synonym name | |||||
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Synonym symbol(s) | DPOA, POLA, DKFZp686K1672, p180, NSX | ||||
EC.number | 2.7.7.7 |
DNA |
TYPE | functioning gene |
STRUCTURE | 303.11 kb 37 Exon(s) |
MAPPING | cloned | Y | linked | N | status | confirmed |
Map | see PRPS2 |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) |
organ(s) |
cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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HOMOLOGY |
interspecies | homolog to murine Pola1 |
Homologene |
FAMILY |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic | |
intracellular,nucleus,nucleoplasm | |
intracellular,nucleus,chromatin/chromosome |
CELLULAR PROCESS | nucleotide, replication |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
cell & other |
REGULATION |
Other | phosphorylatedby CDK2/Cyclin A (may result in a conformational change in POLA2 facilitating its interaction with and activation by hyperphosphorylated retinoblastoma protein (ppRb)) (Takemura 2006) |
ASSOCIATED DISORDERS |
corresponding disease(s) | PDRX , MRXS36 |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |