Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDK11B contributors: mct - updated : 01-09-2010
HGNC name cyclin-dependent kinase 11B
HGNC id 1729
Location 1p36.33      Physical location : 1.571.099 - 1.655.775
Synonym name
  • cell division cycle 2-like 1 (PITSLRE proteins)
  • CDC2 related kinase p58
  • galactosyltransferase-associated protein kinase p58/GTA
  • Synonym symbol(s) p58, PK58, CLK-1, p58CLK-1, p58CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58, CDC2L1, PITSLREA2
    EC.number 2.7.1.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation, tail to tail
    text close to CDC2L2
    STRUCTURE 107.08 kb     21 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure
  • binding sites of transcription factor TCF11, MZF1 with potential effect on regulation of CDC2L1, two Ets-1 sites, one Skn-1 site, and one E2F-1 site
  • a region of nucleotides -152 to +11 necessary for basal transcription of the CDC2L1, GC-rich but is lacking both TATA and CAAT boxes
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 2486 91.2 782 - Xiang (1994)
    also called variant 2/isoform 2
    18 splicing 2226 59.3 526 - Xiang (1994)
    also called variant 3/isoform 3
    19 splicing 2500 85.9 737 - Xiang (1994)
  • also called variant 4/isoform 4
  • translation frame shift
  • 21 splicing 2533 86.8 748 - Xiang (1994)
  • also called variant 5/isoform 5
  • translation frame shift
  • - splicing 1805 52 461 - Xiang (1994)
    also called variant 7/isoform 7
    20 splicing 2480 91.1 780 - Xiang (1994)
    also called variant 8/isoform 8
    20 splicing 2453 90 771 - Xiang (1994)
    also called variant 9/isoform 9
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon highly
    Hearing/Equilibriumearinnercochlea highly
    Lymphoid/Immunelymph node   highly
     thymus    
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Cdc2l1
    homolog to Drosophila Pitslre
    homolog to C.elegans B0495.2
    Homologene
    FAMILY
  • p34Cdc2 protein kinase family
  • SER/THR family of protein kinases
  • CDC2/CDKX subfamily
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text localizes on spindle poles and microtubules (Yokoyama 2008)
    basic FUNCTION
  • playing roles in cell apoptosis
  • acting as a negative regulator of the normal cell cycle progression
  • playing a function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase
  • with CDK8 possess opposing functions in viral activator VP16-dependent transcriptional regulation (Tsutsui 2008)
  • responsible for RanGTP-dependent microtubule stabilization around chromosomes and this local stabilization is essential for normal rates of spindle assembly and spindle function (Yokoyama 2008)
  • playing an important role in normal cell cycle progression
  • promoting ubiquitin/proteasome-mediated degradation of ESR1 (Wang 2009)
  • G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction (Wang 2009)
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    cell life, cell death/apoptosis
    protein, post translation
    PHYSIOLOGICAL PROCESS
    text cell cycle control, protein phosphorylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • CCND3 in the G2M phase
  • repressed ESR1 transcriptional activity (Wang 2009)
  • PAK1 is a new CDK11(p58) substrate (Kong 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS