basic FUNCTION
| playing roles in cell apoptosis |
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acting as a negative regulator of the normal cell cycle progression |
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playing a function in regulating proliferation by the phosphorylation and subsequent plasma membrane targeting of galactosyltransferase |
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with CDK8 possess opposing functions in viral activator VP16-dependent transcriptional regulation (Tsutsui 2008) |
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responsible for RanGTP-dependent microtubule stabilization around chromosomes and this local stabilization is essential for normal rates of spindle assembly and spindle function (Yokoyama 2008) |
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playing an important role in normal cell cycle progression |
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promoting ubiquitin/proteasome-mediated degradation of ESR1 (Wang 2009) |
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G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction (Wang 2009) |