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FLASH GENE
Symbol HOXA3 contributors: mct - updated : 22-08-2011
HGNC name homeo box A3
HGNC id 5104
Location 7p15.3      Physical location : 27.145.809 - 27.166.639
Genatlas name homeo box A3(1E)
Synonym symbol(s) HOX1 , HXA3
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 20.83 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map see HOXA@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3258 - 443 - 2011 21170035
4 - 3396 - 443 - 2011 21170035
- - 2774 - 285 - McAlpine
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta   
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix,DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-1.5
homolog to Drosophila Zen1,Zen2
Homologene
FAMILY ANTP homeobox family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • playing a role in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
  • accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds
  • apical regulator of haemogenic endothelium
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS