SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,ribosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| text
| structural component of the ribosome  |
| basic FUNCTION
| 40S ribosomal protein S6, housekeeping gene |
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having an essential role for proliferation in all cells (Robledo 2008) |
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selective mediator of TRAIL-apoptotic signaling (especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis)(Jeon 2008) |
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plays a positive role in controlling pancreatic beta-cell size and function (Moore 2009) |
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RPS6 in the MTOR pathway regulates blood-testis barrier (BTB) restructuring via its effects on the F-actin organization and protein recruitment at the BTB |
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FOS and RPS6 are induced by the biochemical activation of neurons, and therefore, these markers may be most responsive to stimuli that modulate neurons such as neuro-peptides and biogenic amines |
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RPS6-specific spatiotemporal pattern that is deregulated under conditions of hyperactivated MTOR |
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is a convergence point of cardioprotective signaling, providing positive feedback regulation of CRTC2/AKT1 signaling |
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aggregation of RPS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase |
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possible role of RPS6 phosphorylation in regulating postsynaptic protein synthesis during induction of synaptic plasticity |
