motifs/domains
| a signal peptide, a proregion |
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a protease domain, which alone cleaves truncated procollagen VII within the short telopeptide region into fragments of similar size as the full-length enzyme does |
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an astacin-like protease domain |
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three CUB (protein interaction) domains |
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an EGF like domain between CUBII and CUBIII |
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a supplementary specific HIS domain in BMP1/HIS |
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C-terminal domains of BMP1 are important for substrate recognition and for controlling and restricting its proteolytic activity via exosite binding |
basic FUNCTION
| acting as a procollagen C-proteinase that process the fibrillar collagen types I-III |
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zinc-dependent metalloproteinase that cleaves a variety of extracellular matrix substrates, including type I procollagen |
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may play an important role in the pathogenesis of myelofibrosis in primary myelofibrosis and are apparently induced by cytokines such as TGFbeta-1 |
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might begin to cleave its substrates prior to secretion to the extracellular matrix |
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stimulates the conversion proapo A1 to its phospholipid- (PL-) binding form and it promotes formation of functional HDL and reverse cholesterol transport |
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play key roles in formation of the extracellular matrix (ECM) in vertebrates via biosynthetic processing of precursors into mature functional proteins involved in ECM assembly |
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play key roles in extracellular matrix formation, by converting precursors into mature functional proteins involved in forming the extracellular matrix |
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critically required for mature-collagen generation, downstream of osteoblast maturation, in bone |